SHP2-D26 isomer-1

Overview

SHP2-D26 isomer-1 (Compound 26) is an isomer of SHP2-D26 ( HY-145162 ). SHP2-D26 is the first highly potent SHP2 PROTAC degrader. The induction of SHP2 degradation by SHP2-D26 requires binding to VHL-1 and SHP2 proteins, and is dependent on ubiquitin-like modification and the proteasome . SHP2-D26 can be used in the research of esophageal cancer and acute myeloid leukemia. (Pink: SHP2 ligand ( HY-176796 ); Blue: VHL ligand ( HY-176804 ); Black: linker).

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Others | Products > Research Areas > Others | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Drug Isomer

Product Information

• Catalog No.: HY-145703
• CAS No.: 2740582-16-3
• Molecular Formula: C56H79ClN12O6S2
• Molecular Weight: 1115.89
• Purity: 98.52%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source