PROTAC SOS1 degrader-1

Overview

PROTAC SOS1 degrader-1 is a degrader of SOS1 PROTAC , with a DC 50 of 98.4 nM and a K d value of 44 nM. PROTAC SOS1 degrader-1 induces the formation of a ternary complex with SOS1 and the VCB E3 ubiquitin ligase complex, thereby promoting the ubiquitination and proteasomal degradation of SOS1 . PROTAC SOS1 degrader-1 reduces KRAS -GTP levels, inhibits the phosphorylation of ERK in the RAS-RAF-MEK-ERK pathway, and suppresses the proliferation of cancer cells carrying KRAS mutations. PROTAC SOS1 degrader-1 inhibits tumor growth in mouse xenograft models. PROTAC SOS1 degrader-1 can be used for the research of KRAS -driven cancers. (Pink: SOS1 ligand ( HY-111671 ); Blue: VHL ligand ( HY-112078 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SOS1 | Products > Signaling Pathways > Ras | Products > Signaling Pathways > PERK

Product Information

• Catalog No.: HY-145737
• CAS No.: 2913185-35-8
• Molecular Formula: C57H76ClFN10O4S
• Molecular Weight: 1051.79
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source