JPS014

Overview

JPS014 is a PROTAC degrader targeting HDAC1 , HDAC2 and HDAC3 , with DC 50 values of 0.91 μM, 4.19 μM and 0.64 μM, respectively. JPS014 recruits the VHL E3 ligase to mediate the ubiquitination and proteasomal degradation of HDAC1 , HDAC2 and HDAC3 . JPS014 acts as a submicromolar inhibitor of the HDAC1-CoREST , HDAC2-CoREST and HDAC3-SMRT complexes in vitro. JPS014 increases the level of H3K56ac , reduces the stability of LSD1 and SIN3A , and induces cell apoptosis ( apoptosis ). JPS014 can be used for the research of colon cancer . (Pink: HDAC1 and HDAC2 and HDAC3 ligand ( HY-50934 ); Blue: VHL ligand ( HY-125845 ); Black: linker).

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-145815
• CAS No.: 2669785-76-4
• Molecular Formula: C46H59N7O7S
• Molecular Weight: 854.07
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source