JPS016

Overview

JPS016 is a class I histone deacetylase ( HDAC ) PROTAC inhibitor. JPS016 recruits the VHL E3 ligase ( Ligands for E3 Ligase ) to mediate the ubiquitination and proteasomal degradation of HDAC1 , HDAC2 and HDAC3 . JPS016 reduces the viability of colon cancer cells and induces Apoptosis . JPS016 activates the PINK1 / Parkin mitochondrial Autophagy pathway, enhances cardiomyocyte viability, alleviates mitochondrial damage, and reduces mitochondrial ROS production in cells. JPS016 is applicable to research related to colon cancer and sepsis cardiomyopathy. (Pink: HDAC ligand ( HY-50934 ); Blue: VHL ligand ( HY-125845 ); Black: linker ( HY-175977 )).

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Heart Disease | Products > Disease Areas > Cardiomyopathy | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PINK1/Parkin | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-145816
• CAS No.: 2669785-77-5
• Molecular Formula: C48H63N7O8S
• Molecular Weight: 898.12
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source