JPS036

Overview

JPS036 is a HDAC3 PROTAC degrader with a DC 50 of 0.44 μM. JPS036 recruits the VHL E3 ligase to form a ternary complex with HDAC3 , driving proteasome-mediated degradation. JPS036 is applicable to relevant research on colon cancer . (Pink: HDAC3 Target protein ligand; Blue: VHL ligand ( HY-125905 ); Black: linker ( HY-W105741 )).

Application

Products | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > HDAC

Product Information

• Catalog No.: HY-145819
• CAS No.: 2669785-85-5
• Molecular Formula: C51H66FN7O7S
• Molecular Weight: 940.18
• Purity: 99.31%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (2.66 mM); Clear solution
• Availability: In-stock

Source

Original product source