J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC 50 of 0.039 µM. J-1063 shows anti-fibrotic effect by the inhibition of inflammatory infiltration, collagen deposition, and hepatocytes necrosis. J-1063 has the potential for the research of liver fibrosis.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > TGF-β Receptor
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