5-HT1A/5-HT7 receptor antagonist (5-HT1A Ki = 8 nM, Kb = 0.04 nM; 5-HT7 Ki = 451 nM, Kb = 460 nM) with PDE4B/PDE7A inhibitory activity (PDE4B IC 50 = 80.4 μM; PDE7A IC 50 = 151.3 μM) , its antidepressant like effect is stronger than that of escitalopram as a reference agent.
Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Others | Products > Signaling Pathways > Phosphodiesterase (PDE)
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