COX-2/5-LOX-IN-2 (5b) is a potent and dual inhibitor of COX-2 / 5-LOX . COX-2/5-LOX-IN-2 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-2 shows potent COX-1 , COX-2 and 5-LOX inhibitory activity with IC 50 s of 5.40, 0.01 and 1.78 μM, respectively.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > COX
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