Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC 50 of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC 50 of 295 nM) (WO2018206959A1; example 1).
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Orexin Receptor (OX Receptor)
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