Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC 50 of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC 50 s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively.
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