dTAG-47

Overview

dTAG-47 is a heterobifunctional PROTAC degrader that specifically binds to the FKBP12 F36V domain and Cereblon (CRBN) . By recruiting the CRBN E3 ubiquitin ligase , dTAG-47 induces ubiquitination and proteasomal degradation of FKBP12 F36V -fused Cas9 and tagged KDM5A. dTAG-47 can induce upregulated expression of some endogenous retrovirus (ERV) genes and is suitable for cancer research. (Pink: FKBP12 ligand ( HY-114420 ); Blue: Cereblon ligand ( HY-W087383 ); Black: linker ( HY-42773 )).

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Viral Infection | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > FKBP

Product Information

• Catalog No.: HY-147098
• CAS No.: 2265886-81-3
• Molecular Formula: C59H73N5O14
• Molecular Weight: 1076.24
• Purity: 99.23%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source