LRH-1 agonist-2

Overview

LRH-1 agonist-2 (Compound 6N) is a selective, full LRH-1 agonist with an EC 50 of 15.7 nM. LRH-1 agonist-2 directly interacts with the Thr352 and His390 residues in the LRH-1 binding pocket, promotes allosteric signaling to the activation function surface (AFS), stabilizes the AFS and enhances coactivator recruitment. LRH-1 agonist-2 induces the anti-inflammatory cytokine IL-10 , and reduces the pro-inflammatory cytokines IL-1β and TNFα . LRH-1 modulator-1 exerts anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 can be used in studies related to inflammatory bowel disease.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Inflammatory Bowel Disease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Orphan Nuclear Receptor | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-147105
• CAS No.: 2244781-29-9
• Molecular Formula: C28H36N2O2S
• Molecular Weight: 464.66
• Purity: 98.58%
• Storage: Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (10.76 mM); Clear solution
• Availability: In-stock

Source

Original product source