BPN-15477

Overview

BPN-15477 is an orally active, blood-brain barrier-permeable splicing modulator compound ( SMC ). BPN-15477 restores the correct splicing of exon 20 of the elongator complex protein 1 ( ELP1 ) ( EC 50 = 1.9 μM), thereby significantly increasing the in vivo functional protein levels in all tissues including the brain. BPN-15477 can be used in the research of familial dysautonomia, such as frontotemporal dementia.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Nervous System Injury | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-147149
• CAS No.: 1971086-99-3
• Molecular Formula: C12H10ClN5
• Molecular Weight: 259.69
• Purity: 99.92%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source