RTI-7470-44

Overview

RTI-7470-44 is an orally active and blood-brain barrier-permeable antagonist of trace amine-associated receptor 1 ( hTAAR1 ) with a K i of 0.3 nM. RTI-7470-44 inhibits hTAAR1 -mediated cAMP production and signal transduction ( IC 50 = 8.4 nM), and blocks hTAAR1 -mediated GIRK current responses. RTI-7470-44 increases the spontaneous firing frequency of dopaminergic neurons and reduces collagen-induced platelet aggregation. RTI-7470-44 can be used in studies related to Parkinson's disease and gastric emptying.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Trace Amine-associated Receptor (TAAR)

Product Information

• Catalog No.: HY-147319
• CAS No.: 825658-63-7
• Molecular Formula: C19H11ClF3N5OS
• Molecular Weight: 449.84
• Purity: 99.85%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source