Necrosulfonamide (Standard)

Overview

Necrosulfonamide (Standard) is the analytical standard of Necrosulfonamide ( HY-100573 ). This product is intended for research and analytical applications. Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis , activate the Nrf2 pathway and the downstream antioxidant enzymes , and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways.

Application

Products | Products > Signaling Pathways > Others | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Endocrinology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Necroptosis | Products > Signaling Pathways > Pyroptosis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > Heme Oxygenase (HO) | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > Mixed Lineage Kinase

Product Information

• Catalog No.: HY-100573R
• CAS No.: 1360614-48-7
• Molecular Formula: C18H15N5O6S2
• Molecular Weight: 461.47
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source