Zandatrigine

Overview

Zandatrigine (NBI-921352; XEN901) is a selective, orally active, voltage-gated sodium channel Na V 1.6 /SCN8A inhibitor that can penetrate the blood-brain barrier. Zandatrigine inhibits sodium influx by non-covalently binding to the VSD4 structure of Na V 1.6, blocking the persistent and resuscitative currents under pathological conditions. Zandatrigine can reduce neuronal hyperexcitability and reduce epileptic seizures. Zandatrigine is 134-756-fold selective for other isoforms such as Na V 1.1 and Na V 1.2, and has minimal effect on Na V 1.1 expressed by inhibitory interneurons. Zandatrigine can be used to study Na V 1.6-mediated neuroexcitability diseases such as SCN8A -related developmental epileptic encephalopathy (SCN8A-DEE) and adult focal epilepsy.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Sodium Channel

Product Information

• Catalog No.: HY-147423
• CAS No.: 2154406-04-7
• Molecular Formula: C22H25FN4O2S2
• Molecular Weight: 460.59
• Purity: 99.28%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source