Aleplasinin

Overview

Aleplastinin (PAZ-417) is an orally active, blood-brain barrier permeable, selective SERPINE1 ( PAI-1 ) inhibitor ( IC 50 =655 nM). Aleplastinin activates the tissue type plasminogen activator (tPA) / fibrinolysis cascade by inhibiting PAI-1 , thereby promoting the degradation of amyloid-β (Aβ) oligomers and monomers. Aleplastinin can significantly reduce plasma and brain Aβ levels, improve memory impairment, and reverse cognitive impairment. Aleplastinin can be used for research on Alzheimer's disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > PAI-1 | Products > Signaling Pathways > Amyloid-β

Product Information

• Catalog No.: HY-14759
• CAS No.: 481629-87-2
• Molecular Formula: C28H27NO3
• Molecular Weight: 425.52
• Purity: 99.59%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.08 mg/mL (4.89 mM); Clear solution
• Availability: In-stock

Source

Original product source