AChE/BChE/BACE-1-IN-1

Overview

AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE , BChE , and BACE-1 with IC 50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Cholinesterase (ChE) | Products > Signaling Pathways > Beta-secretase | Products > Signaling Pathways > ROS Kinase

Product Information

• Catalog No.: HY-147658
• CAS No.: 1321361-13-0
• Molecular Formula: C19H21F3N2O
• Molecular Weight: 350.38
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source