AChE/BChE/BACE-1-IN-2

Overview

AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE , BChE , and BACE-1 with IC 50 values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Cholinesterase (ChE) | Products > Signaling Pathways > Beta-secretase | Products > Signaling Pathways > ROS Kinase

Product Information

• Catalog No.: HY-147659
• CAS No.: 1877000-20-8
• Molecular Formula: C18H20F2N2
• Molecular Weight: 302.36
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source