PPARγ/δ modulator 1 (compound 3e) is a potent PPAR modulator. PPARγ/δ modulator 1 is a PPARδ antagonist and a PPARγ partial agonist , with K i values of 14.4 nM and 5.31 μM, respectively. PPARγ/δ modulator 1 has the EC 50 of 7.3 and 12.6 μM for PPARδ corepression and adiponectin production, respectively.
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