HIV-1 inhibitor-40 (Compound 4ab) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an EC 50 of 1.9 nM. HIV-1 inhibitor-40 displays weak CYP sensitivity with IC 50 values of 5.16 μM and 4.51 μM against CYP2C9 and CYP2C19 , respectively. HIV-1 inhibitor-40 has no apparent in vivo acute toxicity.
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