JMI-346 is a potent PfFP-2 ( Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-346 inhibits the growth of CQ S (3D7; IC 50 =13 µM) and CQ R (RKL-9; IC 50 =33 µM) strains of P. falciparum . JMI-346 has the potential to be used as an anti-malarial agent.
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