TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC 50 <0.1 nM for Tb PTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC 50 =0.66 μM).
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