UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC 50 value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide ( HY-126373 ) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes .
Products | Products > Disease Areas > Infection | Products > Disease Areas > Bacterial Infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > β-glucuronidase | Products > Signaling Pathways > Bacterial
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