RSS0680

Overview

RSS0680 is a small noncoding RNA (sRNA) targeting the mRNA ribosome binding site ( RBS ) and a PROTAC . RSS0680 competitively binds to RBS through the conserved CCUCCUCCC anti-Shine-Dalgarno (aSD) sequence and inhibits the translation initiation of target genes. RSS0680 can interact with the DUF1127 protein CcaF1, regulate its own stability and participate in bacterial oxidative stress defense, enhancing the host's resistance to heat shock and oxidative damage by affecting pathways such as C1 metabolism and pyruvate dehydrogenase complex. RSS0680 degrades AAK1 , CDK1 , CDK16 , CDK2 , CDK4 , CDK6 , EIF2AK4 , GAK , LATSl , LIMK2 , MAPK6 , MAPKAPK5 , MARK2 , MARK4 , MKNK2 , NEK9 , RPS6KB1 , SIK2 , SNRK , STK17A , STK17B , STK35 , and WEEl . RSS0680 can be used to study diseases or disorders mediated by aberrant kinase activity and regulatory mechanisms of noncoding RNAs in α-proteobacteria[1][2]. (Pink: CDK1 and CDK2 and CDK4 and CDK6 and CDK16/Cyclin Y ligand ( HY-148070 ); Blue: VHL ligand ( HY-112078 ); Black: linker ( HY-W041970 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Cyclin G-associated Kinase (GAK) | Products > Signaling Pathways > Salt-inducible Kinase (SIK) | Products > Signaling Pathways > LIM Kinase (LIMK) | Products > Signaling Pathways > Wee1 | Products > Signaling Pathways > SnRK | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > CDK | Products > Signaling Pathways > AAK1

Product Information

• Catalog No.: HY-148062
• CAS No.: 2769753-48-0
• Molecular Formula: C52H64N10O6S3
• Molecular Weight: 1021.32
• Purity: 99.85%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (4.90 mM); Clear solution
• Availability: In-stock

Source

Original product source