DB0614

Overview

DB0614 is a PROTAC based on Cereblon ligand, which is a selective and potent targeted protein degrader of NEK9 inhibitor. DB0614 can degrade ABL1 , ABL2, BLK , CDK11B, CDK4 , CSK, EPHA3 , FER, GAK, LIMK1 , MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2 , MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1 , RPS6KA1, RPS6KA3, SIK2 , SIK3 , STK35, TNK2 and ULK1 . DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity.(Blue: Thalidomide-4-OH ( HY-103596 ), Black: linker, Pink: FLT3-IN-17 ( HY-148070 ))

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Autophagy | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > AAK1 | Products > Signaling Pathways > Aurora Kinase | Products > Signaling Pathways > CaMK | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Salt-inducible Kinase (SIK) | Products > Signaling Pathways > LIM Kinase (LIMK) | Products > Signaling Pathways > ULK | Products > Signaling Pathways > PROTACs

Product Information

• Catalog No.: HY-148063
• CAS No.: 2769753-47-9
• Molecular Formula: C41H42N8O7S2
• Molecular Weight: 822.95
• Purity: 99.92%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source