Tri-GalNAc(OAc)3 TFA

Overview

Tri-GalNAc(OAc)3 TFA is a trivalent N-acetylgalactosamine (GalNAc) derivative that can be used to synthesize GalNAc-LYTAC. Tri-GalNAc is a specific ligand targeting the asialoglycoprotein receptor (ASGPR), mediating the endocytosis and transport of cell surface proteins (such as EGFR , HER2) to lysosomes for degradation by lysosomal targeting chimeras ( LYTACs ). Tri-GalNAc significantly reduces the level of target proteins and inhibits downstream signaling pathways (such as EGFR-mediated Akt and MAPK signals). Tri-GalNAc(OAc)3 TFA can be used for hepatocyte targeting studies, and can degrade carcinogenic membrane proteins and inhibit tumor cell proliferation in liver cancer cell models.

Application

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Product Information

• Catalog No.: HY-148118A
• CAS No.: 1159408-65-7
• Molecular Formula: C81H129F3N10O38
• Molecular Weight: 1907.93
• Purity: 98.09%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: 2.5 mg/mL (1.31 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source