U7D-1

Overview

U7D-1 is a USP7 PROTAC degrader that induces selective proteasomal degradation of USP7 . U7D-1 destabilizes and downregulates the expression of variant PRC1 complex subunits PCGF1 , RING1A and PCGF6 , and also slightly reduces the protein level of KDM2B . U7D-1 decreases cell viability, arrests neuroblastoma cells at the G0/G1 cell cycle phase, and downregulates the expression of target genes of PAX3::FOXO1 in FP-RMS cells. U7D-1 increases the level of cleaved PARP in FP-RMS cells, induces cell apoptosis ( apoptosis ), and upregulates the expression of muscle differentiation markers MYH1 and MYF5 . U7D-1 inhibits the growth and proliferation of p53 wild-type and mutant cancer cells, and regulates the apoptosis pathway and E2F pathway. U7D-1 is applicable to studies on neuroblastoma, fusion-positive rhabdomyosarcoma, p53-mutant cancers and cancer-related research. (Pink: USP7 ligand ( HY-49319 ); Blue: Cereblon ligand ( HY-103596 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Neuroblastoma | Products > Disease Areas > CNS Neoplasm | Products > Disease Areas > Muscle Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > E1/E2/E3 Enzyme | Products > Signaling Pathways > Early 2 Factor (E2F) | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Deubiquitinase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MDM-2/p53

Product Information

• Catalog No.: HY-148369
• CAS No.: 3094177-94-0
• Molecular Formula: C53H65N9O7
• Molecular Weight: 940.14
• Purity: 99.68%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.66 mM); Clear solution
• Availability: In-stock

Source

Original product source