Tri-GalNAc-DBCO

Overview

Tri-GalNAc-DBCO is a synthetic ligand composed of three GalNAc units connected to DBCO. Tri-GalNAc-DBCO can act as a ligand for the sialic acid-degrading protein receptor (ASGPR), and can be coupled with targeting proteins or small molecules to form GalNAc-LYTACs. Tri-GalNAc-DBCO specifically binds to ASGPR and, through receptor-mediated endocytosis, guides the coupled molecules to lysosomes for degradation.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > PROTAC | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > LYTACs

Product Information

• Catalog No.: HY-148476
• CAS No.: 2999748-27-3
• Molecular Formula: C82H127N11O29
• Molecular Weight: 1730.94
• Purity: 99.97%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (1.44 mM); Clear solution
• Availability: In-stock

Source

Original product source