trans-ccc_R08 (Compound 1-B) is a cccDNA inhibitor with anti- HBV activity, with an IC 50 of 0.14 μM for HBeAg and an IC 50 of 0.08 μM for HBsAg in in vitro assays. trans-ccc_R08 inhibits covalently closed circular DNA (cccDNA). trans-ccc_R08 is applicable to research related to hepatitis B virus infection .
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