GDC-0134

Overview

GDC-0134 (RG6000) is a modulator targeting dual leucine zipper kinase ( DLK ) that can cross the blood-brain barrier. By inhibiting the kinase activity of DLK, GDC-0134 blocks the activation of the downstream JNK signaling pathway, suppresses DLK-dependent retrograde signal transduction of axon-to-soma degeneration, and exerts neuroprotective activity. GDC-0134 reduces TDP-43 protein aggregation and decreases the degree of neuromuscular junction denervation in motor neurons. GDC-0134 can be used in the research of amyotrophic lateral sclerosis (ALS), Alzheimer's disease and other DLK-related neurodegenerative diseases.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Disease Areas > Amyotrophic Lateral Sclerosis | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > JNK

Product Information

• Catalog No.: HY-148629
• CAS No.: 1637394-01-4
• Molecular Formula: C19H20F4N6O2
• Molecular Weight: 440.39
• Purity: 99.18%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.68 mM); Clear solution
• Availability: In-stock

Source

Original product source