Relutrigine

Overview

Relutrigine (PRAX-562) is an orally active inhibitor of persistent sodium channel . Relutrigine potently and preferentially inhibits persistent I Na induced by ATX-II (Nav 1.5 activator) or the SCN8A mutation N1768D with IC 50 values of 141 nM and 75 nM, respectively. Relutrigine exhibits potent use-dependent block and reduces neuronal intrinsic excitability. Relutrigine has effective anticonvulsant activity.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Sodium Channel

Product Information

• Catalog No.: HY-148792
• CAS No.: 2392951-29-8
• Molecular Formula: C15H11F6N5O2
• Molecular Weight: 407.27
• Purity: 99.33%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (6.14 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source