Vemtoberant (APD418) mesylate is a β 3 -adrenergic receptor ( β 3 -AR ) antagonist with a human K i of 8.2 nM, and exhibits 400- to 600-fold selectivity over human β 1 -AR and β 2 -AR . Vemtoberant mesylate attenuates β 3 -AR-mediated cardiac inhibition. Vemtoberant mesylate can be used for the research of systolic heart failure.
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