GT19630

Overview

GT19630 is a c-Myc PROTAC targeted degrader based on the cereblon E3 ubiquitin ligase , with an IC 50 of 1.5 nM against human c-Myc . GT19630 mediates the degradation of MYC , GSPT1, GSPT2, CK1 alpha , N-Myc , B7-H3 and XIAP , and disrupts the MYC -GSPT1 synergistic regulatory feedback loop. GT19630 inhibits cell proliferation, blocks cell cycle progression at the S phase, promotes cell apoptosis , reduces cell migration capacity, induces integrated stress response, and blocks oxidative phosphorylation by inhibiting the TCA cycle. GT19630 can be used in research related to breast cancer , MYC-driven hematologic malignancies, small cell lung cancer , TP53-mutated cancers, and venetoclax-resistant cancers. (Pink: c-Myc ligand ( HY-168685 ); Blue: Cereblon ligand ( HY-W093472 ); Black: linker ( HY-W015808 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Blood Disease | Products > Disease Areas > Small Cell Lung Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Casein Kinase | Products > Signaling Pathways > CD276/B7-H3 | Products > Signaling Pathways > IAP | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Oxidative Phosphorylation | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > c-Myc

Product Information

• Catalog No.: HY-148837
• CAS No.: 2883535-99-5
• Molecular Formula: C35H30N6O5
• Molecular Weight: 614.65
• Purity: 98.85%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (8.13 mM); Clear solution
• Availability: In-stock

Source

Original product source