CS640

Overview

CS640 (Compound 19) is a chemical probe and a calmodulin-dependent kinase inhibitor. CS640 inhibits CaMK1D , CaMK1B , CaMK1A , CaMK1G , MEK5 , RIPK4 , mLK3 and PIP5K1 , with IC 50 values of 8, 3, 1, 1, 25 nM, 5.69, 2.75 and 11.2 μM, respectively. CS640 blocks Aβ-induced hyperphosphorylation of tau protein at the Thr181 site, but fails to protect primary mouse cortical neurons from Aβ-induced toxic damage. CS640 is applicable to research related to Alzheimer's disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > CaMK | Products > Signaling Pathways > MEK | Products > Signaling Pathways > Mixed Lineage Kinase | Products > Signaling Pathways > RIP kinase | Products > Signaling Pathways > Tau Protein

Product Information

• Catalog No.: HY-148907
• CAS No.: 2388506-83-8
• Molecular Formula: C21H31N7O
• Molecular Weight: 397.52
• Purity: 99.48%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source