NXPZ-2

Overview

NXPZ-2 is an orally active Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with a K i value of 95 nM, EC 50 value of 120 and 170 nM. NXPZ-2 can dose-dependently ameliorate Aβ [1-42] -Induced cognitive dysfunction , improve brain tissue pathological changes in Alzheimer’s disease (AD) mouse by increasing neuron quantity and function. NXPZ-2 can inhibit oxidative stress by increasing Nrf2 expression levels and promoting its cytoplasm to nuclear translocation, which is helpful for Keap1-Nrf2 PPI inhibitors and AD associated disease research .

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > NF-κB | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Keap1-Nrf2

Product Information

• Catalog No.: HY-149010
• CAS No.: 2254492-08-3
• Molecular Formula: C27H27N5O7S2
• Molecular Weight: 597.66
• Purity: 98.55%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 7.14 mg/mL (11.95 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source