Didesmethyl cariprazine

Overview

Didesmethyl cariprazine is an orally active, BBB-permeable metabolite of Cariprazine ( HY-14763 ). Didesmethyl cariprazine is a partial agonist at the D 2 and D 3 receptors, full agonist at the 5-HT 1A receptor, and antagonist at the human 5-HT 2B receptor ( K i : 1.41 nM (human D 2L ), 0.056 nM (human D 3 ), 1.7 nM (human 5-HT 1A ), 0.52 nM (human 5-HT 2B )). Didesmethyl cariprazine dose-dependently inhibits the spontaneous activity of rat midbrain dopaminergic neurons.

Application

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Product Information

• Catalog No.: HY-100658
• CAS No.: 839712-25-3
• Molecular Formula: C19H28Cl2N4O
• Molecular Weight: 399.36
• Purity: 99.63%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source