Bardoxolone

Overview

Bardoxolone (CDDO; RTA 401) is a Nrf2 activator. Bardoxolone shows anti- SARS-CoV-2 3CLpro with IC50 of 27.99 μM. Bardoxolone activates the Nrf2 pathway and inhibits the NF-κB pathway. Bardoxolone can induce cells differentiation, apoptosis and shows antiproliferative activity against cancer cells. Bardoxolone can increase ROS and decrease intracellular GSH levels. Bardoxolone inhibits Z-VAD-FMK ( HY-16658B )-induced necroptosis . Bardoxolone can be used for the research of cancer , inflammation and infection , such as SARS-CoV infection and glioblastoma.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > CNS Neoplasm | Products > Disease Areas > Glioma | Products > Disease Areas > Coronavirus Infection | Products > Disease Areas > Glioblastoma | Products > Disease Areas > SARS-CoV-2 Infection | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Glutathione Peroxidase | Products > Signaling Pathways > Necroptosis | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > SARS-CoV

Product Information

• Catalog No.: HY-14909
• CAS No.: 218600-44-3
• Molecular Formula: C31H41NO4
• Molecular Weight: 491.66
• Purity: 99.50%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 2.5 mg/mL (5.08 mM); Clear solution
• Availability: In-stock

Source

Original product source