Bardoxolone (Standard)

Overview

Bardoxolone (Standard) is the analytical standard of Bardoxolone ( HY-14909 ). This product is intended for research and analytical applications. Bardoxolone is an orally active activator of nuclear regulatory factor ( NRf-2 ) and an inhibitor of SARS-CoV-2 3CL protease . Bardoxolone inhibits SARS-CoV-2 3CL protease with an EC 50 value of 0.43 μM in vero cells. Bardoxolone also inhibits necroptosis in HT-29 cells with an EC 50 value of 1.30 μM by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3 . Bardoxolone can be used in research on COVID-19, TNF-induced systemic inflammatory response syndrome (SIRS), and cerebral ischemia-reperfusion injury.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Coronavirus Infection | Products > Disease Areas > SARS-CoV-2 Infection | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Others | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Necroptosis | Products > Signaling Pathways > SARS-CoV | Products > Signaling Pathways > Virus Protease

Product Information

• Catalog No.: HY-14909R
• CAS No.: 218600-44-3
• Molecular Formula: C31H41NO4
• Molecular Weight: 491.66
• Purity: 98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source