Apricitabine

Overview

Apricitabine (SPD754; AVX754), the (-) enantiomer of 2′-deoxy-3′-oxa-4′-thiocytidine (dOTC), is a highly selective and orally active HIV-1 reverse transcriptase (RT) inhibitor ( K i =0.08 μM), as well as inhibits DNA polymerases α, β, and γ with K i value of 300 μM, 12 μM, and 112.25 μM, respectively. Apricitabine (SPD754; AVX754) shows promising antiretroviral efficacy, good tolerability and a low propensity for resistance selection in antiretroviral-naive HIV infection.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Nucleoside Antimetabolite/Analog | Products > Signaling Pathways > HIV | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-14913
• CAS No.: 160707-69-7
• Molecular Formula: C8H11N3O3S
• Molecular Weight: 229.26
• Purity: 99.8%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source