PROTAC GPX4 degrader-1

Overview

PROTAC GPX4 degrader-1 is a glutathione peroxidase 4 (GPX4) PROTAC degrader with a DC 50 of 30 nM. PROTAC GPX4 degrader-1 induces ROS accumulation and ferroptosis in cancer cells. PROTAC GPX4 degrader-1 inhibits cell growth and reduces GPX4 levels in tumor tissues. PROTAC GPX4 degrader-1 can be used in research related to various cancers including fibrosarcoma, non-small cell lung cancer , and melanoma. (Pink: GPX4 ligand ( HY-401204 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker ( HY-175936 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Glutathione Peroxidase | Products > Signaling Pathways > Ferroptosis

Product Information

• Catalog No.: HY-149236
• CAS No.: 2916433-81-1
• Molecular Formula: C50H57ClN10O10
• Molecular Weight: 993.50
• Purity: 98.53%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (2.52 mM); Clear solution
• Availability: In-stock

Source

Original product source