PptT-IN-4 (Compound 3a) is a PptT inhibitor ( IC 50 : 0.71 μM). PptT-IN-4 inhibits Mtb H37Rv with a MIC value of 42 μM. PptT-IN-4 also inhibits hERG, hCav1.2, and hNav1.5 channels with IC 50 s of 11 μM, 8.1 μM, 6.9 μM respectively.
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