Dim16

Overview

Dim16 is a dual PCSK9 inhibitor and HMG-CoAR inhibitor, with an IC 50 of 0.8 nM against human PCSK9 and an IC 50 of 146.8 μM against HMG-CoAR. Dim16 disrupts the PCSK9 - LDLR protein-protein interaction, inhibits the catalytic activity of HMG-CoAR, enhances cellular uptake of extracellular LDL, and suppresses PCSK9-induced platelet aggregation. Dim16 can be used in research related to hypercholesterolemia.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Hypercholesterolemia | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > PCSK9 | Products > Signaling Pathways > HMG-CoA Reductase (HMGCR)

Product Information

• Catalog No.: HY-149310
• CAS No.: 2743448-32-8
• Molecular Formula: C29H38IN5
• Molecular Weight: 583.55
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source