SP27

Overview

SP27 is a PROTAC PLK4 degrader with an IC 50 of 8.4 nM and a DC 50 of 19.5 nM against PLK4 . SP27 induces PLK4 degradation via the CRBN -dependent ubiquitin-proteasome pathway, inhibits PLK4 downstream signal transduction, and suppresses the growth of TRIM37-amplified breast cancer cells. SP27 is applicable for breast cancer-related research. (Pink: PLK4 ligand ( HY-128493 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Polo-like Kinase (PLK) | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-149324
• CAS No.: 3034805-75-6
• Molecular Formula: C40H40F2N12O5
• Molecular Weight: 806.82
• Purity: 98.87%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source