Sigma-1 receptor antagonist 5

Overview

Sigma-1 receptor antagonist 5 (compound 12)，a 4-pyridylpiperidine derivative with analgesic activity，is an antagonist of sigma receptor (Ki=4.5 nM (σ1R)，10 nM (σ2R)) and histamine H3 (hH 3 R，Ki=7.7 nM， IC 50 =215 nM). Sigma-1 receptor antagonist 5 suppresses Capsaicin-induced nociception with antinociceptive activity and shows potent efficacy in nociceptive and neuropathic pain models.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Sigma Receptor | Products > Signaling Pathways > Histamine Receptor

Product Information

• Catalog No.: HY-149335
• CAS No.: 2952808-33-0
• Molecular Formula: C26H27N3O
• Molecular Weight: 397.51
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source