SIKs-IN-1

Overview

SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases ( SIKs ) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10 , but down-regulates pro-inflammatory cytokine IL-12 . SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Salt-inducible Kinase (SIK)

Product Information

• Catalog No.: HY-149365
• CAS No.: 2927557-06-8
• Molecular Formula: C27H31F2N7O
• Molecular Weight: 507.58
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source