PROTAC BTK Degrader-6

Overview

PROTAC BTK Degrader-6 is an orally active PROTAC -based BTK degrader with a DC 50 of 3.18 nM. PROTAC BTK Degrader-6 induces BTK degradation via proteasomal degradation, ubiquitination, and CRBN ligase recruitment pathways. PROTAC BTK Degrader-6 inhibits NF-κB activation, mRNA expression of IL-1β and IL-6 , as well as the secretion of pro-inflammatory cytokines. PROTAC BTK Degrader-6 reduces inflammatory responses in a zymosan-induced mouse model of peritonitis. PROTAC BTK Degrader-6 can be used in peritonitis-related research. (Pink: Btk ligand ( HY-150885 ); Blue: Cereblon ligand ( HY-45808 ); Black: linker).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Pathogens Infection | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Peritonitis | Products > Disease Areas > Nonalcoholic Steatohepatitis | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Btk | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-149391
• CAS No.: 2767204-39-5
• Molecular Formula: C45H47N11O6
• Molecular Weight: 837.92
• Purity: 99.24%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.98 mM); Clear solution
• Availability: In-stock

Source

Original product source