AD4

Overview

AD4 is an artemisinin derivative that is a proteolytic targeting chimera ( PROTAC ) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells ( IC 50 : 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs

Product Information

• Catalog No.: HY-149428
• CAS No.: 2918262-09-4
• Molecular Formula: C55H78N4O15
• Molecular Weight: 1035.23
• Purity: 98.01%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source