Akt/NF-κB/MAPK-IN-1 (compound 2m) is a potent and orally active inhibitor against NO ( IC 50 =7.70 μM) with no significant toxicity. Akt/NF-κB/MAPK-IN-1 shows anti-inflammatory activity by inhibiting Akt/NF-κB and MAPK signaling pathways.
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