Laccase-IN-1 (compound 4b) is an orally active inhibitor of laccase, with the IC 50 of 11.3 μM. Laccase-IN-1 displays protective and curative effects on apple fruits infected by B. dothidea . Laccase-IN-1 enhances the cell membrane permeability, destroys the mycelial surface morphology and the cell ultrastructure, and reduces the ergosterol and exopolysaccharide contents of B. dothidea .
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